Browsing by Author "Gundersen, Yngvar"
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Aksidentell hypotermi og bruk av rotte som eksperimentell modell
Vaagenes, Per; Gundersen, Yngvar (2000)Accidental hypothermia is an important clinical complication in emergency and disaster medicine. In military medicine even mild hypothermia may seriously influence the soldier’s physiological responses and therefore his ... -
Cardiovascular and thermal strain during 3–4 days of a metabolically demanding cold‑weather military operation
Castellani, John W.; Spitz, Marissa G; Karis, Anthony J.; Martini, Svein; Young, Andrew J; Margolis, Lee M; Karl, J Philip; Murphy, Nancy E; Xu, Xiaojiang; Montain, Scott J; Bohn, Jamie A; Teien, Hilde Kristin; Stenberg, Pål H.; Gundersen, Yngvar; Pasiakos, Stefan M (2017)Background Cardiovascular (CV) and thermal responses to metabolically demanding multi-day military operations in extreme cold-weather environments are not well described. Characterization of these operations will provide ... -
Changes in fibrinogen availability and utilization in an animal model of traumatic coagulopathy
Hagemo, Jostein Skjalg; Jørgensen, Jørgen J.; Ostrowski, Sisse R.; Holtan, Anders; Gundersen, Yngvar; Johansson, Pär I.; Næss, Pål Aksel; Gaarder, Christine (2013)Background Impaired haemostasis following shock and tissue trauma is frequently detected in the trauma setting. These changes occur early, and are associated with increased mortality. The mechanism behind trauma-induced ... -
Changes in intestinal microbiota composition and metabolism coincide with increased intestinal permeability in young adults under prolonged physiologic stress
Karl, J Philip; Margolis, Lee M; Madslien, Elisabeth Henie; Murphy, Nancy E; Castellani, John W.; Gundersen, Yngvar; Hoke, Allison V; Levangie, Michael W; Kumar, Raina; Chakraborty, Nabarun; Gautam, Aarti; Hammamieh, Rasha; Martini, Svein; Montain, Scott J; Pasiakos, Stefan M (2017)The magnitude, temporal dynamics, and physiological effects of intestinal microbiome responses to physiological stress are poorly characterized. This study used a systems biology approach and a multiple-stressor military ... -
Effects of a 7-days military training exercise on inflammatory biomarkers, serum hepcidin, and iron status
McClung, James P; Martini, Svein; Murphy, Nancy E; Montain, Scott J; Margolis, Lee M; Thrane, Ingjerd; Spitz, Marissa G; Blatny, Janet Martha; Young, Andrew J; Gundersen, Yngvar; Pasiakos, Stefan M (2013)Background Hepcidin, a peptide that is released into the blood in response to inflammation, prevents cellular iron export and results in declines in iron status. Elevated serum and urinary levels of hepcidin have been ... -
Effects of exercise mode, energy, and macronutrientinterventions on inflammation during military training
Pasiakos, Stefan M; Margolis, Lee M; Murphy, Nancy E; McClung, Holy L; Martini, Svein; Gundersen, Yngvar; Castellani, John W.; Karl, James P.; Teien, Hilde Kristin; Madslien, Elisabeth Henie; Stenberg, Pål H.; Young, Andrew J.; Montain, Scott J; McClung, James P (2016)Load carriage (LC) exercise may exacerbate inflammation during training. Nutritional supplementation may mitigate this response by sparing endogenous carbohydrate stores, enhancing glycogen repletion, and attenuating ... -
Effects of Infliximab and Hydrocortisone on In Vitro Cytokine Responses after Stimulation with Lipopolysaccharide
Ruud, Tom Erik; Gundersen, Yngvar; Krohn, Claus Danckert; Sveen, Ola; Aasen, Ansgar Oddne (2013)Background: Both glucocorticosteroids and biologic drugs such as the tumor necrosis factor (TNF)-α antagonist infliximab are used often in the treatment of rheumatoid arthritis or inflammatory bowel disease. In severe ... -
Effects of Supplemental Energy on Protein Balance during 4-d Arctic Military Training
Margolis, Lee M; Murphy, Nancy E; Martini, Svein; Gundersen, Yngvar; Castellani, John W.; Karl, James P.; Carrigan, Christopher T; Teien, Hilde Kristin; Madslien, Elisabeth Henie; Montain, Scott J; Pasiakos, Stefan M (2016)Soldiers often experience negative energy balance during military operations that diminish whole-body protein retention, even when dietary protein is consumed within recommended levels (1.5-2.0 g[middle dot]kg-1[middle ... -
Glysin som en del av det akutte resusciteringsregimet etter skuddskader hos gris - modulering av den tidlige inflammatoriske responsen
Gundersen, Yngvar; Vaagenes, Per; Andersen, JM; Dreiem, Anne; Haugen, AH; Myhre, Oddvar; Reistad, Trine; Sterri, Sigrun; Thrane, Ingjerd (2003)As part of a training course in Traumatology and War Surgery organised by the Norwegian Defence Medical Headquarter at Lahaugmoen camp we have used glycine as part of the immediate resuscitation regime after gunshot injuries ... -
HFM-255 "Cold extreme environmental operations" optimizing warfighter performance in extreme cold - momenter fra workshop ved FFI 28.-30. oktober 2014
Gundersen, Yngvar (2015-11-09)I dagene 28. til 30. oktober 2014 arrangerte FFI Workshop HFM-255 med tittelen “Cold Extreme Environmental Operations - Optimizing Warfighter Performance in Extreme Cold”. Omkring 40 eksperter innen kulde og kaldværoperasjoner ... -
Hvordan påvirker temperaturen funksjonen i sirkulerende hvite blodlegemer
Gundersen, Yngvar; Lundeland, Bård; Thrane, Ingjerd; Opstad, Per-Kristian; Vaagenes, Per (2007)Innledning: Intenst fysisk arbeid kan hemme immunforsvaret og øke forekomsten av infeksjoner, særlig i de øvre luftveiene. Samtidig vet vi at slik aktivitet ofte er forbundet med forbigående endringer i kroppstemperaturen. ... -
Kartlegging av tilfredshet med Forsvarets spisemesser
Gundersen, Yngvar; Melnes, Marte; Stenberg, Pål H.; Gulliksrud, Kristine (2016-05-25)Tilbudet i spisemessene bidrar vesentlig til soldatenes trivsel, motivasjon og fysiske yteevne. Denne rapporten presenterer resultater fra en undersøkelse som ble gjennomført i perioden november 2014–februar 2015 for å ... -
Kontrollert mild/moderat hypotermi ved blødningssjokk
Gundersen, Yngvar; Vaagenes, Per; Pharo, Anne; Valø, Elisabeth Try (2000)In a rat model of controlled haemorrhagic shock we have investigated the effects of therapeutic mild/moderate hypothermia on the early inflammatory response and organ function. In two groups of animals (n=13 in each ... -
Kosttilskudd med omega-3-fettsyrer - virkning på immunforsvaret etter langvarig fysiske anstrengelser
Gundersen, Yngvar; Martini, Svein; Thrane, Ingjerd; Holm, Halvor; Stenberg, Pål H. (2012-02-23)Ved sterke fysiske anstrengelser reagerer immunforsvaret med forandringer som likner på dem en ser ved blodforgiftning og større skader, blant annet ved å øke produksjonen av en rekke mediatormolekyler som TNF-α, IL-1 ... -
Markører for overbelastning under en fem-dagers fysisk krevende militærøvelse
Gundersen, Yngvar; Thrane, Ingjerd; Opstad, Per-Kristian; Vaagenes, Per; Lundeland, Bård (2008)Innledning: Intense og langvarige anstrengelser kan redusere den fysiske yteevnen både på grunn av overbelastning og ved at forekomsten av (særlig) øvre luftveisinfeksjoner øker. Det siste kan skyldes den negative påvirkningen ... -
Maternal deprivation of Lewis rat pups increases the severity of experimental periodontitis in adulthood
Breivik, Torbjørn; Gundersen, Yngvar; Murison, Robert; Turner, Jonathan D.; Muller, Claude P.; Gjermo, Per E; Opstad, Per Kristian (2015)Background and Objective: Early life adverse events may influence susceptibility/resistance to chronic inflammatory diseases later in life by permanently dysregulating brain-controlled immune-regulatory systems. We ... -
Regulation of CCN1 (Cyr61) in a porcine model of intestinal ischemia/reperfusion
Shegarfi, Hamid; Krohn, Claus Danckert; Gundersen, Yngvar; Kjeldsen, Signe Flood; Hviid, Claus Vinter Bødker; Ruud, Tom Erik; Aasen, Ansgar Oddne (2015)Intestinal ischemia is a serious condition that may lead to both local and systemic inflammatory responses. Restoration of blood supply (reperfusion) to ischemic tissues often increases the extent of the tissue injury. ... -
Response of circulating immune cells to major gunshot injury, haemorrhage, and acute surgery
Gundersen, Yngvar; Vaagenes, Per; Thrane, Ingjerd; Bogen, Inger Lise; Haug, Kristin Huse; Reistad, Trine; Opstad, Per Kristian (2005)Purpose: The purpose of this study was to use an established porcine model to investigate the effects on immune function of severe gunshot injury. Methods: Twelve pigs sustained two standardised rounds, one through ... -
Severe gunshot injuries in a porcine model: impact on central markers of innate immunity
LUNDELAND, BÅRD; Gundersen, Yngvar; Opstad, Per Kristian; Thrane, Ingjerd; Zhang, Ying; Olaussen, Richard W; Vaagenes, Per (2011)Background The mechanisms behind lipopolysaccharide (LPS) tolerance remain obscure. LPS signals through Toll-like receptor 4 (TLR4) and severe trauma/haemorrhage may influence binding and signalling through this receptor, ... -
Systemic Chemical Desensitization of Peptidergic Sensory Neurons with Resiniferatoxin Inhibits Experimental Periodontitis
Breivik, Torbjørn; Gundersen, Yngvar; Gjermo, Per E; Fristad, Inge; Opstad, Per Kristian (2011)Background and objective: The immune system is an important player in the pathophysiology of periodontitis. The brain controls immune responses via neural and hormonal pathways, and brain-neuro-endocrine dysregulation ...